Casein Kinase

Kinase

Casein Kinase

Casein Kinase Isoform Specific Products:

Casein Kinase Related Products (172)
Antibodies (5)
Casein Kinase Isoform Comparison

By Effects:	Ligand (1) Inhibitors (152) Degraders (5) Antagonists (2) Activator (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-14393S

Emodin-d₄	Inhibitor
Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

HY-155958

Casein kinase 1δ-IN-9	Inhibitor	≥98.0%
Casein kinase 1δ-IN-9 (compound 737) is a potent casein kinase 1δ (CK1δ/CK15) inhibitor. Casein kinase 1δ-IN-9 can be used for the research of neurodegenerative disorders such as Alzheimer's disease.

HY-117332

IQA	Inhibitor
IQA (CGP-029482) is a potent and selective protein kinase CK2 inhibitor.

HY-P3748

Casein Kinase II Receptor Peptide	Chemical
Casein Kinase II Receptor Peptide is a substrate for casein kinase II with an K_m value of 500 µM. Casein Kinase II Substrate can be used for measure casein kinase II activity in crude enzyme preparations.

HY-W011109

CKI-7	Inhibitor
CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases.

HY-170953

QXG-6442	Inhibitor
QXG-6442 is a CK1α Molecular Glue Degrader. QXG-6442 exhibits CK1α degradation potency with a DC₅₀ of 5.7 nM and a D_max of 90%. QXG-6442 induces antiproliferative effects in MOLM-14 cell line.

HY-169692

Casein kinase 1δ-IN-21	Inhibitor
Casein kinase 1δ-IN-21 (compound 501) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-21 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.

HY-171277

Casein kinase 1δ-IN-27	Inhibitor
Casein kinase 1δ-IN-27 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1α, CK1δ, CK1ε, and p38α with IC₅₀s of 22, 16.5, 9.41 and 14.8 nM, respectively. Casein kinase 1δ-IN-27 inhibits the DUX4 expression with an IC₅₀ of 10 nM.

HY-169347

dCK1α-2	Degrader
dCK1α-2 is an orally active CK1α molecular glue degrader that targets p53 pathway-related targets. dCK1α-2 exhibits anti-tumor efficacy in mouse models and can increase the expression of p53-related genes..

HY-170859

AH078	Inhibitor
AH078 (compound 37) is a PROTAC degrader that selectively targets CK1δ and CK1ε, and has low targeting for CK1α. AH078 consists of PROTAC linker (black part) Monomethyl octanoate (HY-W001958), target protein ligand (red part) (HY-170860) CK1δ/CK1ε liagnd-1 and E3 ligase ligand (blue part) E3 ligase Ligand 58 (HY-170861). Among them, E3 ligase ligand + linker can form a conjugate E3 Ligase Ligand-linker Conjugate 163 (HY-170862).

HY-169709

Casein kinase 1δ-IN-26	Inhibitor
Casein kinase 1δ-IN-26 (compound 505) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-26 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.

HY-156913

Casein kinase 1δ-IN-13	Inhibitor
Casein kinase 1δ-IN-13 (compound 401) is a Casein kinase 1δ inhibitor. Casein kinase 1δ-IN-13 can be used in neurodegenerative disease research.

HY-151382

CK2-IN-3	Inhibitor
CK2-IN-3 is a selective and potent CK2 inhibitor (K_d: 12 nM), with IC₅₀ values of 1.51 μM (CK2α) and 7.64 μM (CK2α’). CK2-IN-3 can be used in the research of cancers.

HY-B0183A

Ellagic acid (hydrate)	Inhibitor
Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC₅₀ of 40 nM and a K_i of 20 nM.

HY-155987

CK2-IN-8	Inhibitor
CK2-IN-8 (compound 5c) is a CK2 inhibitor with IC₅₀ >33 μM.

HY-158369

CK2-IN-10
CK2-IN-10 (31), an allosteric CK2 inhibitor, can be used in the research of cancer.

HY-171279

Casein kinase 1δ-IN-29	Inhibitor
Casein kinase 1δ-IN-29 (Compound 18) is the inhibitor for p38α and casein kinase 1 that inhibits p38α, CK1δ and CK1ε with IC₅₀ of 0.041 µM, 0.005 µM and 0.447 µM, respectively. Casein kinase 1δ-IN-29 arrests cell cycle at subG1 phase, induces apoptosis in cell AC1-M88.

HY-169702

Casein kinase 1δ-IN-23	Inhibitor
Casein kinase 1δ-IN-23 (compound 423) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-22 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.

HY-12570

CK2-IN-9	Inhibitor
CK2-IN-9 is a potent and selective inhibitor of CK2 kinase with an IC₅₀ of 3 nM. CK2-IN-9 reduces Wnt reporter activity with an IC₅₀ of 75 nM. CK2-IN-9 has low exposure (AUC=0.36 μM/h) and high clearance (CL=65 mL/min/kg) properties in rat.

HY-162078

Antiproliferative agent-46	Inhibitor
Antiproliferative agent-46 (compound 5e) is an inhibitor of the casein kinase-2 enzyme (CK2) receptor. Antiproliferative agent-46 has a potent antiproliferative activity with an IC₅₀ value of 5.75 μM on the U87 cell line.

IWP-2	CK1δ, IC₅₀: 40 nM		99.93%
Silmitasertib		CK2α, IC₅₀: 1 nM CK2α', IC₅₀: 1 nM	99.94%
Emodin		CK2α Wild-type, IC₅₀: 5.9 μM (at ATP concentration is 50 μM) CK2α Wild-type, IC₅₀: 1.4 μM (at ATP concentration is 10 μM)	99.25%
Ellagic acid		CK2, IC₅₀: 40 nM	99.75%
MGD-28	CK1α, DC₅₀: 7.8 nM		99.73%
CK1δ-IN-10	CK1δ, IC₅₀: 0.255 μM
D4476	CK1, IC₅₀: 0.3 μM		99.94%
PF-670462 dihydrochloride	CKIδ, IC₅₀: 14 nM		99.96%
TBB		CK2, IC₅₀: 0.15 μM (Human CK2)	98.54%
Silmitasertib sodium salt		CK2α, IC₅₀: 1 nM CK2α', IC₅₀: 1 nM	99.92%
BTX-A51	CKIα		98.58%
TMX-4116	CK1α		99.76%
FPFT-2216	CK1α		99.75%
PF-4800567	CKIδ, IC₅₀: 711 nM		99.69%
SR-3029	CKIδ, IC₅₀: 44 nM		99.73%
DMAT		CK2, IC₅₀: 0.13 μM (Human CK2)	98.09%
IC261	CKIδ, IC₅₀: 1 μM CkIα1, IC₅₀: 16 μM		99.54%
SGC-CK2-1		CK2α, IC₅₀: 36 nM CK2α', IC₅₀: 16 nM	99.67%
AMG-548 dihydrochloride	CK1		99.86%
TAK-715	CK1δ CK1ε		99.76%
LY294002 hydrochloride		CK2, IC₅₀: 0.098 μM CK2α2, IC₅₀: 3.869 μM	99.93%
PF-5006739	CK1δ, IC₅₀: 3.9 nM		99.56%
CKI-7 free base	CK1, IC₅₀: 6 μM CK1, Ki: 8.5 μM		99.80%
BioE-1115		CK2α, IC₅₀: 10 μM	99.56%
CK2/ERK8-IN-1		CK2, IC₅₀: 0.5 μM CK2, Ki: 0.25 μM	≥99.0%
TTP 22		CK2, IC₅₀: 100 nM	98.40%
DEG-77	CK1α, DC₅₀: 10 nM		98.31%
CK1-IN-1	CKIδ, IC₅₀: 15 nM CK1ε, IC₅₀: 16 nM		99.19%
Hematein		CKII, IC₅₀: 0.74 μM
MU1742	CKIδ		99.74%
Casein Kinase 2 Substrate Peptide		CK2	98.47%
TA-01	CKIδ, IC₅₀: 6.8 nM		99.86%
CK2 inhibitor 2		CK2, IC₅₀: 0.66 nM	98.51%
TBCA		CK2, IC₅₀: 110 nM CK2, Ki: 77 nM	99.45%
ON 108600		CK2α2, IC₅₀: 0.005 μM CK2α1, IC₅₀: 0.05 μM	99.73%
LH846	CKIδ, IC₅₀: 290 nM CKIα, IC₅₀: 2.5 μM		98.18%
TMX-4113	CK1α		99.08%
Casein Kinase inhibitor A86	CKIα		99.26%
Longdaysin	CKIα, IC₅₀: 5.6 μM CKIδ, IC₅₀: 8.8 μM		99.83%
PI-828		CK2, IC₅₀: 149 nM CK2α2, IC₅₀: 1.127 μM	99.62%
BRD4/CK2-IN-1		CK2, IC₅₀: 230 nM	98.21%
CK1-IN-2	CKIα, IC₅₀: 123 nM		99.54%
NCC007	CKIα, IC₅₀: 1.8 μM CKIδ, IC₅₀: 3.6 μM		99.22%
MRT00033659	CKIδ, IC₅₀: 0.9 μM		99.77%
Quinalizarin		CK2, Ki: ~50 nM CK2, IC₅₀: 110 nM
SRPIN803		CK2, IC₅₀: 203 nM	99.17%
AMG-548	CK1		≥99.0%
(R)-DRF053 dihydrochloride	CK1, IC₅₀: 14 nM		99.30%
A-3 hydrochloride	CK1, Ki: 80 μM	CK2, Ki: 5.1 μM	99.75%
Casein kinase 1δ-IN-1	CKIδ		99.91%
SR-1277	CKIδ, IC₅₀: 49 nM
Casein kinase 1δ-IN-9	CK1δ		≥98.0%
IQA		CK2
Casein Kinase II Receptor Peptide		CK2, Km: 500 μM
CKI-7	CK1, IC₅₀: 6 μM CK1, Ki: 8.5 μM
QXG-6442	CK1α, DC₅₀: 5.7 nM
Casein kinase 1δ-IN-27	CK1ε, IC₅₀: 9.41 nM CK1δ, IC₅₀: 16.5 nM CK1α, IC₅₀: 22 nM
CK2-IN-3		CK2α, IC₅₀: 1.51 μM CK2α', IC₅₀: 7.64 μM
Ellagic acid (hydrate)		CK2, Ki: 20 nM CK2, IC₅₀: 40 nM
Casein kinase 1δ-IN-29	CKIδ, IC₅₀: 0.005 μM CK1ε, IC₅₀: 0.447 μM
Casein kinase 1δ-IN-4	CK1δ		≥98.0%
SR-4133	CK1ε, IC₅₀: 58 nM CK1δ, IC₅₀: 10 μM
GSK-3β/CK-1δ-IN-1	CK-1δ, IC₅₀: 0.57 μM
CK2-IN-13		CK2, IC₅₀: 5.8 nM
Casein kinase 1δ-IN-3	CKIδ, pIC₅₀: 6.5376 M		99.93%
PIM-1/CK2-IN-2		CK2
Casein kinase 1δ-IN-10	CK1δ
TID43		CK2, IC₅₀: 0.3 μM
CK1-IN-3	CK1δ, IC₅₀: 2.22 μM		99.00%
CK2/PIM1-IN-1		CK2, IC₅₀: 3.787 μM
CK1-IN-4	CKIδ, IC₅₀: 2.74 μM
Casein kinase 1δ-IN-16	CKIδ
AMG-548 hydrochloride	CK1
CK1δ-IN-3	CKIδ
Emodin (Standard)		CK2α Wild-type
CK2 inhibitor 4		CK2, IC₅₀: 3.8 μM
Casein kinase 1δ-IN-28	CK1ε, IC₅₀: 14.6 nM
EGFR-IN-57		CK2α, IC₅₀: 0.171 μM
Casein kinase 1δ-IN-15	CK1δ, IC₅₀: 0.045 μM
WAY-606344	CK1δ
Multi-kinase-IN-6		CK2, IC₅₀: 0.09 μM
Casein kinase 1δ-IN-5	CK1δ, IC₅₀: 47 nM
Casein kinase 1δ-IN-17	CKIδ
Casein kinase 1δ-IN-18	CKIδ
HDAC/CK2-IN-1		CK2, IC₅₀: 3.67 μM
CK1δ-IN-9	CKIδ, IC₅₀: 1.4 nM
TMCB		CK2α, Ki: 83 nM CK2α', Ki: 21 nM
CK2 inhibitor 3		CK2, IC₅₀: 280 nM
Casein kinase 1δ-IN-31	CK1δ, IC₅₀: 17 nM CK1α, IC₅₀: 196 nM
p38α inhibitor 8	CK1δ, IC₅₀: 0.202 μM
4,5,6,7-Tetrabromo-1H-benzimidazole		CK2
CK2-IN-14		CK2, IC₅₀: 0.66 nM
CK2-IN-12		CK2, IC₅₀: 0.8 μM
CSNK2-IN-2		CK2

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Casein Kinase

Casein Kinase

Casein Kinase Isoform Specific Products:

Casein Kinase Isoform Specific Products:

Casein Kinase Related Products (172)

Antibodies (5)

Casein Kinase Isoform Comparison

Casein Kinase Related Products (172):