2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  4. Casein Kinase

Casein Kinase

Casein Kinase

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Casein Kinases (CKs), a group of ubiquitous Ser/Thr kinases, regulate a wide range of cellular functions in eukaryotes, including phosphorylation of proteins that are substrates for degradation via the ubiquitin-proteasome system (UPS). Two casein kinases, casein kinase-1 (CK-1) and casein kinase-2 (CK-2), have been characterized from many sources.

CK1 kinases exist in at least seven isoforms (α, β, γ1-3, δ, and ɛ) in mammals and CK1 kinases phosphorylate various substrates to play vital roles in diverse physiological processes such as DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis. Casein kinase 2 (CK2) is a highly pleiotropic serine-threonine kinase, which catalyzed phosphorylation of more than 300 proteins that are implicated in regulation of many cellular functions, such as signal transduction, transcriptional control, apoptosis, and the cell cycle.

Casein Kinase Isoform Specific Products:

Casein Kinase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156913
    Casein kinase 1δ-IN-13
    		Inhibitor
    Casein kinase 1δ-IN-13 (compound 401) is a Casein kinase 1δ inhibitor. Casein kinase 1δ-IN-13 can be used in neurodegenerative disease research.
    Casein kinase 1δ-IN-13
  • HY-151382
    CK2-IN-3
    		Inhibitor
    CK2-IN-3 is a selective and potent CK2 inhibitor (Kd: 12 nM), with IC50 values of 1.51 μM (CK2α) and 7.64 μM (CK2α’). CK2-IN-3 can be used in the research of cancers.
    CK2-IN-3
  • HY-B0183A
    Ellagic acid (hydrate)
    		Inhibitor
    Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM.
    Ellagic acid (hydrate)
  • HY-155987
    CK2-IN-8
    		Inhibitor
    CK2-IN-8 (compound 5c) is a CK2 inhibitor with IC50 >33 μM.
    CK2-IN-8
  • HY-12570
    CK2-IN-9
    		Inhibitor
    CK2-IN-9 is a potent and selective inhibitor of CK2 kinase with an IC50 of 3 nM. CK2-IN-9 reduces Wnt reporter activity with an IC50 of 75 nM. CK2-IN-9 has low exposure (AUC=0.36 μM/h) and high clearance (CL=65 mL/min/kg) properties in rat.
    CK2-IN-9
  • HY-162078
    Antiproliferative agent-46
    		Inhibitor
    Antiproliferative agent-46 (compound 5e) is an inhibitor of the casein kinase-2 enzyme (CK2) receptor. Antiproliferative agent-46 has a potent antiproliferative activity with an IC50 value of 5.75 μM on the U87 cell line.
    Antiproliferative agent-46
  • HY-148328
    CK2-IN-4
    		Inhibitor 99.24%
    CK2-IN-4 (compound 5) is a protein kinase (CK2) inhibitor (IC50=8.6 µM). CK2-IN-4 has good potential for research in the areas of cancer, viral infections and glomerulonephritis.
    CK2-IN-4
  • HY-153747
    Casein kinase 1δ-IN-4
    		Inhibitor ≥98.0%
    Casein kinase 1δ-IN-4 (compound 567) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-4 has the potential for the research of Alzheimer's disease.
    Casein kinase 1δ-IN-4
  • HY-149292
    SR-4133
    		Inhibitor
    SR-4133 is a potent and highly CK1ε selective inhibitor with an IC50 of 58 nM. SR-4133 binds to the ATP-binding site of CK1ε. SR-4133 displays nanomolar growth inhibition of bladder cancer cells, and inhibits the phosphorylation of 4E-BP1.
    SR-4133
  • HY-153866A
    CK1-IN-2 hydrochloride
    		Inhibitor
    CK1-IN-2 (compound Nr.4) hydrochloride is a potent CK1 inhibitor with an IC50 values of 123, 19.8, 26.8, 74.3 nM for CK1a, CK1d, CK1e, p38a, respectively.
    CK1-IN-2 hydrochloride
  • HY-156662
    Casein kinase 1δ-IN-7
    		Inhibitor
    Casein kinase 1δ-IN-7 (compound 497) is a Casein kinase 1δ inhibitor. Casein kinase 1δ-IN-7 can be used in the study of neurodegenerative disorders such as Alzheimer's disease.
    Casein kinase 1δ-IN-7
  • HY-169985
    CK2-IN-13
    		Inhibitor
    CK2-IN-13 (compound 12c) is a potent inhibitor of CK2, with the IC50 of 5.8 nM. CK2-IN-13 plays an important role in cancer research.
    CK2-IN-13
  • HY-P4056
    CIGB-300
    		Antagonist
    CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase CK2. CIGB-300 induces apoptosis in multiple tumor cell lines and can be used in cancer research.
    CIGB-300
  • HY-148455
    Casein kinase 1δ-IN-3
    		Inhibitor 99.93%
    Casein kinase 1δ-IN-3 (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.
    Casein kinase 1δ-IN-3
  • HY-168517
    PIM-1/CK2-IN-2
    		Inhibitor
    PIM-1/CK2-IN-2 (compound 3aA) is a PIM-1/CK2 inhibitor. PIM-1/CK2-IN-2 can induce the mitochondrial apoptotic pathway in CCRF-CEM cells. PIM-1/CK2-IN-2 can be used in cancer research.
    PIM-1/CK2-IN-2
  • HY-156040
    Casein kinase 1δ-IN-10
    		Inhibitor
    Casein kinase 1δ-IN-10 is a casein kinase 1δ (CK1δ) inhibitor (WO2012080729A2; compound 685).
    Casein kinase 1δ-IN-10
  • HY-168615
    MGD-28
    		Degrader
    MGD-28 is a potent, orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. In addition, MGD-4 also degrades CK1α (DC50=7.8 nM). MGD-28 has antiproliferative activity and can be used in multiple myeloma research.
    MGD-28
  • HY-120267
    TID43
    		Inhibitor
    TID43 is a CK2 inhibitor, with an IC50 of 0.3 μM. TID43 can be used for anti-angiogenic research.
    TID43
  • HY-128433
    CK1-IN-3
    		Inhibitor 99.00%
    CK1-IN-3 (compound 51) is a AC1 inhibitor with an IC50s 2.22 µM for CK-1δ.
    CK1-IN-3
  • HY-135816
    CK2/PIM1-IN-1
    		Inhibitor
    CK2/PIM1-IN-1 is an inhibitor of CK2 and PIM1, with IC50s of 3.787 μM and 4.327 μM for CK2 and PIM1, respectively. CK2/PIM1-IN-1 is developed for the research of proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, vascular disorders, pathogenic infections and certain immunological disorders.
    CK2/PIM1-IN-1
Cat. No. Product Name / Synonyms Application Reactivity
Casein Kinase Isoform Comparison

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